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Using MRI to explore why we can experience muscle weakness after exercise

09 October 2024

Unaccustomed eccentric exercise can result in the development of muscle soreness and a loss of muscle strength and power in the days following exercise. The cause of these negative effects remains poorly understood. This study aims to use novel sodium-MRI scanning to investigate differences that occur in the amount of sodium which is inside and outside of muscle cells (and their relationship to the loss and recovery of muscle power) the days following an eccentric exercise training session.

Requirements

  • Criteria
  • • Male
  • • Aged 18-35 yrs at the time of signing the informed consent.
  • • BMI 18-27 kg/m2
  • • No regular exercise (i.e. <2 times per week)

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Ethical approval

The study was approved by the University of Nottingham Medical School Ethics Committee on 14th August 2024 in accordance with the Declaration of Helsinki.

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